MAP seminar

2023.02.10 お知らせ

14th MAP Seminar Report

Date: February 10, 2023

Speaker: Dr. Katayama, Dr. Wang and Dr. Mizobuchi

On February 10, 2023, we held the 14th MAP seminar, and gathered here. Three speakers presented their research in English, Dr. Katayama, Dr. Wang and Dr. Mizobuchi.

The first is Dr. Katayama. His research is about the influence of recipient age on the complications after pediatric liver transplantation. He described the definition and score of several postoperative complications, of which GWRBW is one of the important factors affecting the transplantation function after liver transplantation. Finally he showed the conclusion that the incidence of C-D Ill complications were lower in the infant group than in the non-infant group. And GWRBW was independently associated with the incidence of C-D Ill complications. During the discussion, One student asked about the meaning and differences represented by several line graphs. Dr. Katayama gave a series of answers and gave some examples.

The second speaker was Dr. Wang. The title of his research was decreased expression of hyaluronan synthase and the anterior tibial fascial damage of the rat model of chemotherapy-induced peripheral neuropathy. He described the behavioral evaluation including skin and muscle of vincristine-induced chemotherapy-like rat model, and divided the rats into ns group and different concentrations of VCR group. And he found that the administration of VCR led to the change of Hyaluronan synthase and the decrease of a new type of cell-fasciacytes, fascia damage. Everyone also discussed this research.

Finally, Dr. Mizobuchi presented his research: Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. His research demonstrated ketamine may have improving effects on fentanyl tolerance, in which the conformational changes in GRK and β-arrestin interaction in MOR signaling could be involved and modified by ketamine. And present results suggest that ketamine, at doses within the range of clinical concentrations, improved desensitization induced by fentanyl may in part explain the effectiveness of ketamine against opioid tolerance in the clinical practice. Then we had a discussion. This study leads us to think further about reducing opioid medications in the clinic. His research has been published in the journal of biomolecules.

In this MAP seminar, three speakers presented in English and refined their research in an active discussion with the participants. The professor also commented on and summarized each speaker’s presentation. Despite the different areas of research, participants were able to gain new approaches to their research from the different presentations. We are looking forward to the next seminar.

Ruilin Wang