Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine

2022.03.27 お知らせ

Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine.

2022 Mar 10;12(3):426.

doi: 10.3390/biom12030426.

Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine

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Cardiopulmonary Resuscitation May Not Stop Glutamate Release in the Cerebral Cortex

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2022 Mar 10.

doi: 10.1097/ANA.0000000000000838. Online ahead of print.

Cardiopulmonary Resuscitation May Not Stop Glutamate Release in the Cerebral Cortex

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Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats

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2022 Mar 16;17(3):e0265512.

doi: 10.1371/journal.pone.0265512. eCollection 2022.

Protective effect of tin chloride on rhabdomyolysis-induced acute kidney injury in rats

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Free PMC article

 

 

6th MAP seminar

2022.03.12 お知らせ

6th MAP Seminar Report

 

Date: March 11, 2022

Speaker: Dr. Nakatsuka, Dr. Shen and Dr. Manabe

 

We conducted our 6th MAP seminar on March 11, 2022. 17 members participated in this seminar. Three presenters presented their research in English, Dr. Nakatsuka, Dr. Shen and Dr. Manabe.

The first was Dr. Nakatsuka, whose study was on the association between adrenergic receptor (AR) and GLT-1 with mirror image pain (MIP). Dr. Nakatsuka observed change of GLT-1 by α1 antagonist in vitro and observed change of MIP by α1 antagonist in vivo. He showed the effect of the α1 AR antagonist phentolamine on MIP. MIP did not completely recover after intrathecal phentolamine administration. He discussed a variety of substances may contribute to MIP. In conclusion, intrathecal α1 antagonist administration in SNI model rat ammolite MIP and decrease in spinal GLT-1 may induce MIP. During the discussion session, a student asked if long-acting α1 agonists had been considered as a comparison. In response, Dr. Nakatsuka pointed out that the subjects were rats, and that long-acting α1 agonists can cause a sustained hypotensive state that can affect the results of the experiment. For other questions, Dr. Nakatsuka also provided answers.

Next was Dr. Shen, his study was on the relationship between blood glucose level and intraoperative hypothermia. According to previous studies, Dr. Shen hypothesized that patients with poorly controlled preoperative blood glucose level are at higher risk for the development of intraoperative hypothermia. He found postinduction glucose level is an independent risk factor associated with intraoperative hypothermia. During the discussion, a physician asked what mechanism causes hypothermia to be more prevalent in patients with lower blood glucose levels. In response, Dr. Shen explained that the literature suggests that lower blood glucose levels directly affect thermogenesis and therefore lead to more hypothermia. Professor stated that we cannot explain much of the mechanism for a retrospective study, better prospective studies are expected in the future.

Finally, Dr. Manabe presented his research: Compared analysis of two downstream signaling pathways above μ-opioid receptor with opioid. Dr. Manabe showed the result that each opioid’s induced internalization, fentanyl’s concentration-dependent induced internalization and multiple administration’s effect on internalization. He found that only fentanyl may strongly induce internalization and pretreatment of hydromorphone might inhibit fentanyl induced internalization. Dr. Manabe slides used a lot of pictures to make the study easier to understand and was praised by professor for its smooth presentation.

In this MAP seminar, three presenters gave presentations in English and other participants actively participated in the discussion. On the one hand, we practiced our English skills, and on the other hand, we expanded our research horizons. It was very beneficial for both the presenters and the participants. We look forward to the next seminar.

 

Shen Zhangtian

ベストクラス受賞

2022.03.10 お知らせ